Eccentric Cycling Training Improves Erythrocyte Antioxidant and Oxygen Releasing Capacity Associated with Enhanced Anaerobic Glycolysis and Intracellular Acidosis

The antioxidant capacity of erythrocytes protects individuals against the harmful effects of Jewelry Dish oxidative stress.Despite improved hemodynamic efficiency, the effect of eccentric cycling training (ECT) on erythrocyte antioxidative capacity remains unclear.This study investigates how ECT affects erythrocyte antioxidative capacity and metabo

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Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections

ABSTRACTCongenital hearing loss is a common chronic condition affecting children in both developed and developing nations.Viruses correlated with congenital hearing loss include human cytomegalovirus (HCMV) and Zika virus (ZIKV), which causes congenital Zika syndrome.The mechanisms by which HCMV and ZIKV infections cause hearing loss are poorly und

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PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells

Abstract Single-cell RNA-seq quantifies biological heterogeneity across both discrete cell types and continuous cell transitions.Partition-based Jewelry Dish graph abstraction (PAGA) provides an interpretable graph-like map of the arising data manifold, based on estimating connectivity of manifold partitions (https://github.com/theislab/paga).PAGA

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